Peripheral blood nutrient indices as biomarkers for anti‑PD‑1 therapy efficacy and prognosis in patients with advanced gastric cancer

Immunotherapy offers survival benefits for patients with advanced gastric cancer, but not all populations can benefit from immunotherapy. Good nutritional status is fundamental to a patient's immune function and may have an impact on the efficacy of The present study aimed investigate changes in prognostic index (PNI), lung cancer inflammation (ALI) albumin‑globulin ratio (AGR) values before after immunotherapy cancer. also determine potential association aforementioned patient outcomes prognosis. Body mass (BMI), serum albumin, total protein, peripheral blood lymphocyte, neutrophil, carcinoembryonic antigen (CEA), carbohydrate antigen19‑9 (CA19‑9) a‑fetoprotein (AFP) data were collected 195 who underwent January 2020 October 2021. In addition, PNI, ALI AGR calculated based variables within 3 days prior weeks results demonstrated that low PNI was associated elevated CEA levels. Moreover, levels reduced BMI levels, AFP PD‑L1 negative first‑line treatment. Comparison responding non‑responding groups revealed responded had higher than did respond, both treatment, lower CA19‑9 Furthermore, group, decreased increased following treatment compared those objective response disease control rates high groups, respectively. found be independent predictors short‑term cut‑off 47.18 1.29, Univariate analysis progression‑free (PFS) patients, while multivariate baseline PFS. conclusion, tumor progression leads decline level indicated effective alleviate this deterioration certain extent. exhibit predicting prognosis as biomarkers clinical practice.